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翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク BI 224436 ： ウィキペディア英語版 BI 224436 BI 224436 is an investigational new drug under development for the treatment of HIV infection. BI 224436 is the first non-catalytic site integrase inhibitor (NCINI). It inhibits HIV replication via binding to a conserved allosteric pocket of the HIV integrase enzyme. This makes the drug distinct in mechanism of action compared to raltegravir and elvitegravir, which bind at the catalytic site.〔Levin, Jules. (BI 224436, a Non-Catalytic Site Integrase Inhibitor, is a potent inhibitor of the replication of treatment-naïve and raltegravir-resistant clinical isolates of HIV-1. ) Conference Reports for NATAP. ICAAC Chicago Sept 17-20 2011.〕 In October 2011, Gilead Sciences purchased exclusive rights to develop BI 224436 and several related compounds under investigation in Boehringer Ingelheim’s noncatalytic site integrase inhibitor program.〔(Gilead Negotiates Worldwide License to BI’s Early Clinical Stage HIV Program ). Genetic Engineering and Biotechnology News. 6 Oct 2011.〕〔Highleyman, Liz. (ICAAC: New Integrase Inhibitor BI 224436 Active against Raltegravir-Resistant HIV ). HIVandHepatitis.com. 7 Oct 2011.〕 ==References== 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「BI 224436」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.